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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Multi-targeted therapy resistance via drug-induced secretome fucosylation

    Mark Borris D Aldonza, Junghwa Cha ... Yoosik Kim
    Targeted therapies induce an aberrant fucosylation of complex tumor secretomes stimulating the expansion of minority drug-resistant clones and promoting therapy resistance.
    1. Plant Biology

    The plant pathogen Pseudomonas aeruginosa triggers a DELLA-dependent seed germination arrest in Arabidopsis

    Hicham Chahtane, Thanise Nogueira Füller ... Luis Lopez-Molina
    Arabidopsis seed germination can be repressed by a Pseudomonas factor.
    1. Neuroscience

    The severity of microstrokes depends on local vascular topology and baseline perfusion

    Franca Schmid, Giulia Conti ... Bruno Weber
    The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.
    1. Chromosomes and Gene Expression

    Genetic dissection of the RNA polymerase II transcription cycle

    Shao-Pei Chou, Adriana K Alexander ... Charles G Danko
    Natural genetic variation reveals how DNA sequence impacts core transcriptional processes of initiation, pause, and termination.
    1. Computational and Systems Biology
    2. Neuroscience

    Shared and modality-specific brain regions that mediate auditory and visual word comprehension

    Anne Keitel, Joachim Gross, Christoph Kayser
    The comprehension of acoustic and visual speech depends on modality-specific pathways in the brain, which explains why auditory speech abilities and lip reading are not associated in typical adults.
    1. Neuroscience

    Impact of blindness onset on the representation of sound categories in occipital and temporal cortices

    Stefania Mattioni, Mohamed Rezk ... Olivier Collignon
    Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic, Bennett William Fox ... Erik C Andersen
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Neuroscience

    Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations

    Limei Zhang, Vito S Hernandez ... Lee E Eiden
    Placing the PACAP/PAC1 signaling within glutamate/GABA cell type and subregional contexts in mouse brain reveals its conspicuous role for sensorimotor circuit interaction through modulating neuronal plasticity.
    1. Neuroscience

    Body size as a metric for the affordable world

    Xinran Feng, Shan Xu ... Jia Liu
    The human body shapes how we perceive and interact with the environment, with body size serving as a boundary for defining potential actions, hereby enlightening research on foundation agents.
    1. Chromosomes and Gene Expression

    Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

    R A Greenstein, Stephen K Jones ... Bassem Al-Sady
    Heterochromatin spreading in fission yeast predominantly produces intergenerationally unstable outcomes, requiring an accessory element that represses histone turnover.