10,011 results found
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
    1. Neuroscience

    Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

    Alberto Llera, Thomas Wolfers ... Christian F Beckmann
    Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.
    1. Neuroscience

    Structure and function of axo-axonic inhibition

    Casey M Schneider-Mizell, Agnes L Bodor ... Nuno Maçarico da Costa
    Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.
    1. Neuroscience

    Heritability and cross-species comparisons of human cortical functional organization asymmetry

    Bin Wan, Şeyma Bayrak ... Sofie L Valk
    Human brain suggests an asymmetric organization along a functional cortical axis describing a hierarchical functional trajectory from perceptual/action to abstract cognition, which is heritable and comparable with macaque brain, suggesting (phylo)genetic conservation and adaptation.
    1. Microbiology and Infectious Disease

    Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth

    Nikos Nikolopoulos, Renata C Matos ... François Leulier
    D-alanylated lipoteichoic acids support Drosophila juvenile growth.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

    Ravi Vijayvargia, Raquel Epand ... Ihn Sik Seong
    Structural and biochemical analysis of full-length huntingtin protein illuminates the impact of the polyglutamine region on its structure and function.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana, Simona Cocco, Rémi Monasson
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Neuroscience

    Differential increase of hippocampal subfield volume after socio-affective mental training relates to reductions in diurnal cortisol

    Sofie Louise Valk, Veronika Engert ... Tania Singer
    Socio-emotional behavioral intervention links to changes in the structure and function of hippocampal subfields, in particular CA1-3, and reductions in cortisol levels in healthy adults.
    1. Neuroscience

    Spatial and temporal pattern of structure–function coupling of human brain connectome with development

    Guozheng Feng, Yiwen Wang ... Ni Shu
    Multimodal brain connectome analysis reveals patterns of structure–function coupling and links their developmental changes to cognitive function and transcriptomic architecture.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng, Xianchi Dong ... Timothy A Springer
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.

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