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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion

    Yann Duroc, Rajeev Kumar ... Valérie Borde
    Meiotic cells employ a specific pathway to limit the amount of gene conversion occuring at recombination sites.
    1. Chromosomes and Gene Expression

    Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin

    Jacob M. Miller, Sydney Prange ... Irene Chiolo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig, Marcy Diaz ... Peter Walter
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Plasmodium falciparum translational machinery condones polyadenosine repeats

    Slavica Pavlovic Djuranovic, Jessey Erath ... Sergej Djuranovic
    Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.
    1. Chromosomes and Gene Expression

    Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length

    Shanaya Shital Shah, Stella Hartono ... Wolf-Dietrich Heyer
    The dsDNA-dependent motor protein Rdh54 antagonizes Rad51-Rad54-mediated D-loop formation during homologous recombination and restricts the length of D-loops.
    1. Chromosomes and Gene Expression

    Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

    Daphne R Knudsen-Palmer, Pravrutha Raman ... Antony M Jose
    Experimental results and computational modeling reveal many factors that influence if a gene can be efficiently silenced using RNA interference.
    1. Microbiology and Infectious Disease

    Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

    Jean-Emmanuel Hugonnet, Dominique Mengin-Lecreulx ... Michel Arthur
    Production of the L,D-transpeptidase YcbB and elevated synthesis of the (p)ppGpp alarmone reveals a new mode of peptidoglycan polymerization that bypasses the D,D-transpeptidase activity of PBPs and leads to broad-spectrum β-lactam resistance in Escherichia coli.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Toxin-based screening of C-terminal tags in Escherichia coli reveals the exceptional potency of ssrA-like degrons

    Patrick C. Beardslee, Karl R. Schmitz
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    Abigail Knecht, Denise Sirias ... Karine A Gibbs
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Genetics and Genomics

    Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

    Anthony J Veltri, Karole N D'Orazio ... Rachel Green
    Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
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