5,256 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

    Kasper R Andersen et al.
    Components of the nuclear pore complex share structural and functional features with soluble nuclear transport receptors, which suggests that there may be an evolutionary relationship between these two types of protein.
    1. Neuroscience

    Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum

    Marta Maltese et al.
    Structural and functional striatal synaptic plasticity abnormalities occur early in a sensitive developmental period, representing a potential unique endophenotypic traits that increase the risk of manifesting clinical symptoms in DYT1 mutation carriers.
    1. Neuroscience

    Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

    Andrea Ferrario et al.
    A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport

    Justin D Walter et al.
    The cryo-EM structure and functional characterization of the chloride-selective ion transporter Slc26a9 defines its oligomeric architecture and transport mechanism.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

    Ravi Vijayvargia et al.
    Structural and biochemical analysis of full-length huntingtin protein illuminates the impact of the polyglutamine region on its structure and function.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The accessory helix of complexin functions by stabilizing central helix secondary structure

    Daniel T Radoff et al.
    A deeply conserved feature of complexin's secondary structure underlies its inhibitory function despite poor primary sequence conservation.
    1. Structural Biology and Molecular Biophysics

    Structural and functional characterization of an otopetrin family proton channel

    Qingfeng Chen et al.
    Structural and functional analysis of the OTOP3 channel from Xenopus tropicalis offers insights into the mechanism of ion transport and regulation in the otopetrin proton channel family.
    1. Neuroscience

    Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

    Alberto Llera et al.
    Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.
    1. Neuroscience

    Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception

    Carl J Hodgetts et al.
    Structure-function associations in medial temporal lobe reflect specialised, behaviourally-relevant neurocognitive circuits for the perception of faces and places.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach et al.
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.

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