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    1. Cell Biology

    Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

    Laura Vuolo, Nicola L Stevenson ... David J Stephens
    Genetic knock-outs of the dynein-2 intermediate chains reveals that both are essential for correct cilia function and transition zone organization, but play different functions in the assembly of dynein-2 motor and in primary cilia formation.
    1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina, Karin Schuster-Gossler ... Achim Gossler
    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
    1. Physics of Living Systems

    Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system

    Sarah Schuster, Timothy Krüger ... Markus Engstler
    Trypanosome development within the transmitting tsetse fly reveals essential adaptations of microbial motility to diverse physical microenvironments.
    1. Cell Biology

    A bioactive peptide amidating enzyme is required for ciliogenesis

    Dhivya Kumar, Daniela Strenkert ... Betty A Eipper
    Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

    Paul Capewell, Christelle Cren-Travaillé ... Annette MacLeod
    African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Trypanosomiasis: Skin deep

    Aitor Casas-Sánchez, Álvaro Acosta-Serrano
    Version of Record
    Insight
    1. Ecology
    2. Evolutionary Biology

    Extreme adaptations for aquatic ectoparasitism in a Jurassic fly larva

    Jun Chen, Bo Wang ... Jes Rust
    Well-preserved fossils reveal an extreme morphological specialization of fly larvae, and broaden our understanding of the diversity of ectoparasitism in Mesozoic insects.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram, Nicola G Jones ... Markus Engstler
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.