Browse the search results

Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.

African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.

The parasite that causes African sleeping sickness can be transmitted from mammals to tsetse flies in two stages of its lifecycle, rather than one as was previously thought.

We are writing to respond to the comment by Matthews and Larcombe, 2022 on our article about the life cycle of Trypanosoma brucei (Schuster et al., 2021).

A trypanosome DYRK kinase that exhibits fundamental differences to conventional DYRK family regulation links parasite quorum sensing, signal transduction and developmental gene expression.

The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.

Parasite life cycles may be more flexible than traditionally thought, potentially allowing single-cell infections of insect vectors and transmission between hosts even at very low parasite densities.

We are writing to comment on the article by Schuster et al., 2021 about the life cycle of Trypanosoma brucei.