Sex differences in the age-related decline of blood-brain barrier function vary across brain regions, with a more pronounced decrease observed in males beginning in the early 60s.

A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.

Ultrastructure expansion microscopy unlocks new fundamental cell biology of malaria parasites, providing new insights into processes including establishment of cell polarity, organelle biogenesis, and organelle fission.

Intracellular growth of the bacterial pathogen Legionella pneumophila in the amoeba Dictyostelium discoideum implicates a bacterial fatty acid transporter as well as dynamic interactions of the distinct membrane-bound replication compartment with host cell lipid droplets.

Signals from primate rod photoreceptors do not exhibit the light-level-dependent routing through parallel retinal circuits observed in rodents and often invoked in interpreting psychophysical experiments.

Two intrinsic factors converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice.

Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.

Single-molecule localization imaging shows that the Nipah virus fusion protein forms nanoscale clusters on cell and viral membranes that favor membrane fusion activation.

Mitochondrial fusion enables a metabolic transition during spermatogenesis.

HIV escapes human immune pressure through a single mutation in V2 domain of envelope protein leading to emergence of mutant-specific broadly reactive antibodies, a phenomenon recapitulated in combinatorial vaccine design.