1,829 results found
    1. Cell Biology
    2. Neuroscience

    Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

    Ronit Ilouz, Varda Lev-Ram ... Susan S Taylor
    High-resolution, large-scale immunohistochemical mouse brain images showing global views of different brain regions, as well as cellular and subcellular details, identified distinct localization of PKA RIβ and RIIβ regulatory subunits that reveal functional differences.
    1. Cell Biology
    2. Neuroscience

    Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

    Veronica Cloud, Ada Thapa ... Ryan D Mohan
    An unbiased biochemical screen reveals a direct link between gene regulation and actin cytoskeleton remodeling.
    1. Cell Biology
    2. Computational and Systems Biology

    Global, quantitative and dynamic mapping of protein subcellular localization

    Daniel N Itzhak, Stefka Tyanova ... Georg HH Borner
    A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, resolving all major organelles.
    1. Cell Biology
    2. Neuroscience

    Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

    Domenica Ippolito, Dominique A Glauser
    A refined analysis of the mechanisms controlling CaM kinase-1 subcellular localization in sensory neurons, a cell-autonomous process known to control nociceptive plasticity and to adjust avoidance behaviors.
    1. Computational and Systems Biology

    Statistical analysis supports pervasive RNA subcellular localization and alternative 3' UTR regulation

    Rob Bierman, Jui M Dave ... Julia Salzman
    Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dynamic subcellular localization of a respiratory complex controls bacterial respiration

    François Alberge, Leon Espinosa ... Axel Magalon
    The localization of respiratory complexes in the cell membrane emerges as a critical factor for controlling respiration in bacteria.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A subcellular map of the human kinome

    Haitao Zhang, Xiaolei Cao ... Bin Zhao
    An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    Richard Panayiotou, Francesc Miralles ... Richard Treisman
    G-actin binding controls the susceptibility of MRTF-A to phosphorylation, which works in concert with multiple NES elements to regulate MRTF-A subcellular localisation and activity.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu, Yolanda T Chong ... Alan M Moses
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Neuroscience

    Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

    David Exposito-Alonso, Catarina Osório ... Beatriz Rico
    Neuregulins control the integration of specific excitatory and inhibitory synapses through subcellular sorting.

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