Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.

Increased usability and validity of neuroscience models, through FAIR workflows for the whole modeling process, including data and model management, parameter estimation, uncertainty quantification, and model analysis.

Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.

Endogenous modulation of pain relief perception is based on its motivational content and enhanced by increased dopamine availability with no significant effects of a pharmacological opioidergic manipulation in healthy volunteers.

A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.

Computational models of large-scale cortical dynamics, integrating gene expression mapping to pattern pharmacological modulation across cortex, capture inter-areal topographies of functional connectivity alterations induced by lysergic acid diethylamide, providing a framework for simulating effects of pharmacology in the human brain.

Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.

Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.

Repeatedly activating negative memory-bearing cells produces cellular and behavioral abnormalities.