1,298 results found
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

    Bert van de Kooij et al.
    The human NimA-related kinases (Neks) recognize divergent substrate motifs, and include Nek10 as a dual-specificity serine/tyrosine kinase, and Nek6, Nek7 and Nek9 as amplifiers of the Plk1 phospho-motif.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

    Hisashi Tatebe et al.
    Sin1, a regulatory subunit of TOR protein kinase, has an evolutionarily conserved domain that specifically binds and recruits substrate for phosphorylation, and may represent a potential target for anti-cancer drugs.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen et al.
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

    Neel H Shah et al.
    A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez et al.
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

    Ruming Chen et al.
    The biochemical basis for coupling cytoskeletal dynamics to regulated protein synthesis has been revealed.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TOR Signaling: A central role for a region in the middle

    Edward Stuttfeld et al.
    A domain called the 'Conserved region in the middle' is responsible for target recognition in the TORC2 complex in fission yeast and the mTORC2 complex in mammals.
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    1. Structural Biology and Molecular Biophysics

    Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

    Homa Majd et al.
    It is technically difficult to identify transport proteins, but here a method is presented that exploits the principle that they are stabilized in detergent solution when they bind their substrate.
    1. Cell Biology
    2. Developmental Biology

    Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

    Jennifer Winstanley et al.
    The in vivo activity of Tolloid during Drosophila dorsal-ventral patterning is regulated by the differential specificity of its non-catalytic domains in mediating substrate and Collagen IV interaction.

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