2,867 results found
    1. Biochemistry and Chemical Biology

    Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

    Masatoshi Miyamoto et al.
    (O-Acyl)-ω-hydroxy fatty acids and their derivatives, produced by the fatty acid ω-hydroxylase Cyp4f39, form a lipid polarity gradient in the lipid layer of the tear film and prevent dry eye.
    1. Evolutionary Biology

    Structural color in Junonia butterflies evolves by tuning scale lamina thickness

    Rachel C Thayer et al.
    Artificial selection on wing color and CRISPR/Cas9 knockout of the optix gene both alter scale lamina thickness in Junonia coenia, which shifts structural color wavelength and mimics macroevolutionary butterfly diversity.
    1. Cell Biology

    A protein quality control pathway at the mitochondrial outer membrane

    Meredith B Metzger et al.
    Temperature-sensitive mitochondrial outer membrane proteins used as novel quality control substrates reveal a unique mitochondria-associated degradation pathway consisting of both cytosolic and mitochondrial ubiquitin-proteasome system machinery.
    1. Microbiology and Infectious Disease

    An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

    Mathieu Cayla et al.
    A trypanosome DYRK kinase that exhibits fundamental differences to conventional DYRK family regulation links parasite quorum sensing, signal transduction and developmental gene expression.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

    Nicola Alessio et al.
    Protein IGFBP-4 acts as a genotoxic stress mediator that, entering into circulation after its secretion by senescent cells, could promote further senescence phenomena in non-injured cells thus impairing tissues’ homeostasis.
    1. Ecology
    2. Plant Biology

    Determining the scale at which variation in a single gene changes population yields

    Erica McGale et al.
    Variation in the gene NaMPK4 in plant populations increases reproductive yield, an effect which appears to be independent of soil water availability, neighbor-scale interactions and associations with arbuscular mycorrhizal fungi.
    1. Biochemistry and Chemical Biology

    Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

    Xiaojuan Ma et al.
    Mechanistic insight into the chaperone-like activity of NMNAT to phosphorylated Tau reveals a connection between NAD+metabolism and Tau homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

    Andrea Ruiz-Velasco et al.
    Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
    1. Neuroscience

    Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

    Maria Ryazantseva et al.
    Glutamatergic projections from basolateral to central amygdala, implicated in neuropsychiatric disorders, develop rapidly during early postnatal period and their development is modulated via endogenously active kainate receptors.

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