2,521 results found
    1. Developmental Biology
    2. Neuroscience

    How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits

    Julia L Meng et al.
    In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu et al.
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

    Xuchen Hu et al.
    Macrophages release 30-nm vesicular particles enriched in accessible cholesterol during cellular locomotion, a discovery that is likely relevant to cholesterol disposal by these cells.
    1. Evolutionary Biology

    Molecular function limits divergent protein evolution on planetary timescales

    Mariam M Konaté et al.
    Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
    1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba et al.
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Cell Biology

    A critical role of VMP1 in lipoprotein secretion

    Hideaki Morishita et al.
    The ER transmembrane protein VMP1 is important for release of lipoproteins from the ER membrane into the ER lumen for secretion.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

    Isabella Vlisidou et al.
    The insect pathogenic bacterium Photorhabdus has evolved astonishing nano-scale analogues of hypodermic syringes that it uses to inject toxins into host cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

    Charles F Ericson et al.
    Bacteria produce a syringe-like structure, loaded with a single protein within the lumen of its needle-like tube, that is sufficient for stimulating animal metamorphosis.

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