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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

    F Donelson Smith et al.
    Structural analysis of an AKAP18-protein kinase A complex reveals that regions of intrinsic disorder impact the phosphorylation of preferred substrates.
    1. Cell Biology
    2. Developmental Biology

    Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

    Jennifer Winstanley et al.
    The in vivo activity of Tolloid during Drosophila dorsal-ventral patterning is regulated by the differential specificity of its non-catalytic domains in mediating substrate and Collagen IV interaction.
    1. Biochemistry and Chemical Biology

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Matthew E Cockman et al.
    Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters

    Mary Hongying Cheng et al.
    Novel evidence on the molecular determinants of the dual function, anion permeation and substrate transport, of excitatory amino acid transporters opens avenues toward illuminating how these transporters regulate synaptic function and contribute to neurological conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

    Edward J Brignole et al.
    Cryo-electron microscopy structures of human ribonucleotide reductase reveal molecular details of substrate selection and allosteric inhibition through assembly of its large subunit into a ring that excludes its small subunit.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a AAA+ unfoldase in the process of unfolding substrate

    Zev A Ripstein et al.
    The structure of a substrate-engaged AAA+ unfoldase suggests a model for processive unfolding that is supported by biochemical data.
    1. Structural Biology and Molecular Biophysics

    Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

    Rina Rosenzweig et al.
    Multiple chaperone binding sites on substrates suggest a mechanism by which the Hsp70 chaperone can circumvent kinetic traps in protein folding.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding

    Tristan A Bell et al.
    The AAA+ protein unfolding motor ClpX grips substrates with the uppermost part of its substrate-binding pore, and requires interactions with hydrophobic amino acid side chains to operate with optimal efficiency.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu et al.
    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers et al.
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.