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    1. Developmental Biology

    Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in Drosophila

    Rajaguru Aradhya, Monika Zmojdzian ... Krzysztof Jagla
    Adult muscle precursors (AMP) cells in Drosophila send out filopodia to interact with neighbouring muscles, which drive the reactivation of AMPs via an Insulin-Notch-Myc cascade.
    1. Physics of Living Systems

    Quantifying gliding forces of filamentous cyanobacteria by self-buckling

    Maximilian Kurjahn, Antaran Deka ... Stefan Karpitschka
    The self-buckling behavior of filamentous cyanobacteria allowed a quantification of their propulsion forces, indicating that adhesion plays an important role in gliding motility.
    1. Cell Biology

    Dnmt3a is an epigenetic mediator of adipose insulin resistance

    Dongjoo You, Emma Nilsson ... Sona Kang
    Mouse and tissue culture studies reveal that adipose DNA methyltransferase 3a mediates insulin resistance, partially through repressing the expression of FGF21.
    1. Neuroscience

    Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos

    Evan L Ardiel, Andrew Lauziere ... Hari Shroff
    Systematic analysis of behavioral maturation in the Caenorhabditis elegans embryo reveals a stereotyped developmental progression, including rhythmic behavioral quiescence elicited by a sleep-promoting neuron (RIS) releasing somnogenic peptides (FLP-11).
    1. Neuroscience

    Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

    Amanda M Brown, Joshua J White ... Roy V Sillitoe
    Genetic, pharmacologic, and optogenetic manipulations demonstrate that Purkinje cells can trigger and propagate the signals for tremor.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper, Lev Tsimring, Jeff Hasty
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Cancer Biology
    2. Computational and Systems Biology

    Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

    Takuya Kato, Robert P Jenkins ... Erik Sahai
    Cancer invasion occurs with different molecular and spatial patterns, thin invading strands are associated with mesenchymal cell features, such as low cell-cell adhesion, while broad strands are favoured for lymph node metastasis and require high matrix proteolysis and cell-cell adhesions.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku, Jason B Muhitch ... Sharon S Evans
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Neuroscience

    Role of anterior insula cortex in context-induced relapse of nicotine-seeking

    Hussein Ghareh, Isis Alonso-Lozares ... Nathan J Marchant
    The anterior insula cortex is a critical neural substrate of context-induced relapse of nicotine-seeking.
    1. Neuroscience

    Control of parallel hippocampal output pathways by amygdalar long-range inhibition

    Rawan AlSubaie, Ryan WS Wee ... Andrew F MacAskill
    Amygdala input to ventral hippocampus is both excitatory and inhibitory, and the balance of these two projections controls the formation of place preference via differential innervation of each hippocampal output population.