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Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.

Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.

A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.

Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.

The genomic features associated with a gene fate to loss have been retained for approximately 500 million years during evolution, and the genes with these features exhibit restricted expression profiles, leading to the genes being less important.

Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.

The SPARC complex directs accurate RNAPII positioning for transcription initiation and, in some instances, ensures correct transcription directionality in Trypanosoma brucei.

A designed system to track homologous recombination (HR) in vivo demonstrates the importance of chromosome organization in the induction of global mobility in response to double-strand breaks and characterizes the role of two types of global motility in HR.

During epigenetic transcriptional memory in budding yeast, histone H3 lysine 4 dimethylation - dependent on Nup1000 and independent of RNA polymerase II - regulates binding of a critical transcription factor and, once established, is mitotically heritable for at least four cell divisions.