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Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.

Multi-omic analyses reveal that the chromatin-associated microrchidia protein, MORC (PF3D7_1468100), at the blood stage of the human malaria parasite, Plasmodium falciparum, interacts with a range of nuclear proteins.

The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.

Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.

While SET-2 methylates histone H3K36 during transcription, ASH1 methylates this residue in repressed regions, is important for silencing, and can both positively and negatively influence methylation of histone H3K27.

Expression of the lamina-associated polypeptide α (LAP2α) prevents premature cellular ageing caused by expression of progerin in Hutchinson-Gilford progeria syndrome.

Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.

Telomere-specific depletion of Rap1, the main sequence-specific telomere-binding protein in Saccharomyces cerevisiae, can be tolerated due to the presence of secondary telomere capping mechanisms, which may help explain the rapid evolution of budding yeast telomeres.

Horizontal gene transfer (HGT) analysis in polyextremophile red algae (Cyanidiales) provides explanations for the nonexistence of cumulative effects and eukaryotic pangenomes, and highlights differences between HGT and native genes.

A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.