46 results found
    1. Neuroscience

    Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning

    James Peak et al.
    Direct and indirect pathway neurons in posterior dorsomedial striatum were found to play distinct roles, with the former necessary for encoding and the latter for updating goal-directed learning.
    1. Neuroscience

    Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients

    Shenghong He et al.
    Patients with Parkinson's disease can be trained to self-suppress beta bursts in subthalamic nucleus, which was accompanied by quicker reaction times when prompted to move but increased tremor.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience

    The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs

    Ryan S Phillips et al.
    The effects of chloride homeostasis can explain diverse responses of basal ganglia output neurons to putatively inhibitory inputs and may tune these neurons' synchrony, oscillations and behavior in decision-making scenarios.
    1. Medicine
    2. Neuroscience

    What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

    Dan Valsky et al.
    Aberrant striatal signaling does not induce drastic changes in the spontaneous discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia.
    1. Neuroscience

    Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

    Hirofumi Fujita et al.
    Medial cerebellar nucleus comprises five major types of excitatory projection neurons differentially connected with specific subsets of inferior olive neurons, Purkinje cells, and somatomotor, oromotor, positional-autonomic, orienting and arousal circuits.
    1. Computational and Systems Biology
    2. Neuroscience

    Dopamine role in learning and action inference

    Rafal Bogacz
    A mathematical model describes the function of dopaminergic neurons in both learning and action planning.
    1. Neuroscience

    Globus pallidus dynamics reveal covert strategies for behavioral inhibition

    Bon-Mi Gu et al.
    Rats can pre-position the state of their basal ganglia neural networks to adaptively influence their subsequent response to a Go signal.
    1. Neuroscience

    Temporal cascade of frontal, motor and muscle processes underlying human action-stopping

    Sumitash Jana et al.
    The sequence of neural and physiological processes underlying action-stopping has been delineated.
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer et al.
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.

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