1,219 results found
    1. Cancer Biology

    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

    SungEun Kim et al.
    Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina

    Jasper J Visser et al.
    An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
    1. Cancer Biology
    2. Cell Biology

    Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer

    Christina R Adams et al.
    The GLI2 transcription factor is a master regulator of the aggressive basal-like subtype of pancreatic cancer and enables adaptation to oncogenic KRAS ablation.
    1. Neuroscience

    Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties

    Michael V Lombardo et al.
    Functional hypoconnectivity between ‘social brain’ default mode circuitry and visual association cortex underpins a subtype of autistic toddlers with a strong preference to attend to the non-social visual world.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou et al.
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Cell Biology
    2. Developmental Biology

    Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

    Deborah Morena et al.
    The functional relevance of stem cell niche perturbation in sarcomagenesis is defined and the mouse model presented provides a rationale for the use of combination therapy for the treatment of genetically heterogeneous sarcomas.
    1. Cancer Biology

    Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

    Tim DD Somerville et al.
    A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.
    1. Neuroscience

    Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    Timothy S Balmer, Laurence O Trussell
    Distinct inputs to the cerebellum make contact on specific subtypes of target neurons.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Neuroscience

    Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

    Nathan P Achilly et al.
    The loss of Mecp2 results in cerebellar dysfunction that contributes to the motor deficits in Rett syndrome.

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