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    1. Neuroscience

    A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain

    Naoyuki Matsumoto et al.
    Sonic hedgehog signaling is crucial for the self-renewal of outer radial glial cells and gyrus formation of the cerebral cortex in gyrencephalic mammals.
    1. Developmental Biology

    Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina

    Brent S Wells et al.
    TGFβ family members instruct a cell fate decision downstream of stochastic signaling in the Drosophila retina to ensure correct pairing between different color photoreceptors for color vision.
    1. Neuroscience

    Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus

    Tenzin Ngodup et al.
    A major new class of neuronal cell type has been discovered in the auditory system, having features that make it a critical component of auditory processing.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

    Syn Kok Yeo et al.
    The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.
    1. Cancer Biology

    Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

    Shun Kishimoto et al.
    Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structural basis for subtype-specific inhibition of the P2X7 receptor

    Akira Karasawa, Toshimitsu Kawate
    Crystal structures of a mammalian P2X7 receptor and structure-based functional studies reveal a novel drug-binding site and subtype-specific conformational rearrangements required for channel opening.
    1. Neuroscience

    Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

    Amanda Klein et al.
    MRGPRD and MRGRPX1 are co-expressed in primate DRG neurons, but β-alanine and BAM8-22, preferentially activate CMH-subclasses, and co-activating different cutaneous nociceptors by pruritogens does not change itch sensation to pain.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Stem Cells and Regenerative Medicine

    In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

    Weida Li et al.
    Combinations of transcription factors can convert pancreatic acinar cells into endocrine α-, β- and δ-cells in vivo.
    1. Developmental Biology

    Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

    Roberto Quaranta et al.
    Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.