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Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21^st century.

Polyunsaturated fatty acid analogues show selectivity for different cardiac ion channels, suggesting their potential use for the treatment of different subtypes of Long QT Syndrome.

Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.

Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.

Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.

Lack of cardiac MKK6 results in premature death with the development of heart hypertrophy and cardiac dysfunction in aging.

Most chloroquine regimens trialled for the treatment of COVID19 will not result in life-threatening cardiovascular toxicity.

Epigenomic signatures overlapping disease-associated variants from genome-wide association studies help prioritize new variants in sub-threshold loci whose biological relevance is experimentally confirmed.

A genetically diverse panel of subject-specific induced pluripotent stem cells models the in vitro susceptibility of cardiac cells to develop a cardiotoxic drug response.

Computer simulations show how low-intensity illumination can be used to terminate cardiac arrhythmias.