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    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
    1. Cell Biology

    Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

    Susumu Hirabayashi, Ross L Cagan
    The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
    1. Genetics and Genomics

    Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage

    Carla Gonçalves et al.
    Comparative genomics coupled with genetic and biochemical studies show that central carbon metabolism in fungi can be remodeled by genes originating from bacteria.
    1. Evolutionary Biology

    Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

    Meihua Christina Kuang et al.
    Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A receptor and neuron that activate a circuit limiting sucrose consumption

    Ryan M Joseph et al.
    Although sugar-sensing taste neurons typically promote feeding, a taste neuron in the Drosophila pharynx limits feeding via the IR60b receptor; thus, revealing a new element in the circuit logic of feeding control.
    1. Ecology

    Tritrophic metabolism of plant chemical defenses and its effects on herbivore and predator performance

    Ruo Sun et al.
    Genetic manipulation demonstrates the costs and benefits of detoxifying glucosinolate plant defenses in a pest insect and its predator.
    1. Biochemistry and Chemical Biology

    De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

    Erich Stefan et al.
    By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
    1. Neuroscience

    Immediate perception of a reward is distinct from the reward’s long-term salience

    John P McGinnis et al.
    The experiences that are most rewarding at the time are not necessarily those that are remembered long-term.
    1. Neuroscience

    Learning the specific quality of taste reinforcement in larval Drosophila

    Michael Schleyer et al.
    The finding that fly maggots, equipped with only 10,000 neurons, process reinforcement not only by value but also by specific quality reveals a basic operating principle of brains and challenges current models of memory organization.