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Human Biology and Medicine
Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
Alenka Guček et al.
Live cell imaging shows that the cAMP-sensor Epac2, a target of major antidiabetic drugs, is central to fusion pore control during insulin granule exocytosis.
Structural Biology and Molecular Biophysics
Activation mechanism of ATP-sensitive K
channels explored with real-time nucleotide binding
Michael Puljung et al.
A combined FRET- and electrophysiology-based approach is used to study ATP/ADP ADP binding to the stimulatory nucleotide binding site of ATP-sensitive K+ channels and investigate their activation mechanism.
Potassium dependent rescue of a myopathy with core-like structures in mouse
M Gartz Hanson et al.
A mouse model of human muscle myopathy is used to provide mechanistic insight, identify possible biomarkers of disease, and suggest possible therapeutic strategies to alleviate muscle weakness.
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