Karin Purshouse, Elias T Friman ... Wendy A Bickmore
In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather increased transcriptional efficiency.
Abril Angélica Escamilla-Ayala, Ragna Sannerud ... Wim Annaert
Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
Chong Li, Marie R Culhane ... Montserrat Torremorell
Vaccination has the potential to decrease swine influenza diversification by restricting influenza virus co-infections and reassortment events in pigs.
A toxin is used to introduce an otherwise cell-impermeant fluorophore-antibody (or some thing which is equally specific) to bind to an intracellular protein which allows for super resolution imaging and single particle tracking inside the living cell.
Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
Alexandre Chojnowski, Peh Fern Ong ... Oliver Dreesen
Expression of the lamina-associated polypeptide α (LAP2α) prevents premature cellular ageing caused by expression of progerin in Hutchinson-Gilford progeria syndrome.
Arjun Narayanan, Anatoli Meriin ... Ibrahim I Cisse
Quantitative single molecule and super resolution imaging in mammalian cells reveal a population of precursor aggregates describable by first order phase transition theory.
Two-photon imaging reveals super-sparse responses to natural images in primate V1, which carry sufficient information for discrimination of the input natural images with high accuracy.
