Browse the search results

Page 2 of 119
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis et al.
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure

    Romain F Laine et al.
    Machine learning in conjunction with super-resolution imaging allows for the first time to quantitatively analyse large and heterogenous virus samples structure at a high throughput and specificity.
    1. Cell Biology
    2. Neuroscience

    Developmental mechanism of the periodic membrane skeleton in axons

    Guisheng Zhong et al.
    Super-resolution imaging reveals how the skeleton that supports the outer membrane of axons is assembled during development, and provides an explanation for why this structure preferentially forms in axons but rarely in dendrites.
    1. Immunology and Inflammation

    Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

    Praneeth Chitirala et al.
    A new knock-in mouse endogenously labels cytotoxic granules and can be used with all modern super-resolution imaging techniques to study T cell function in vitro and in vivo.
    1. Neuroscience

    Correlating STED and synchrotron XRF nano-imaging unveils cosegregation of metals and cytoskeleton proteins in dendrites

    Florelle Domart et al.
    The development of high-resolution correlative imaging of metals and proteins reveals the interaction of copper and zinc with the synaptic architecture of neurons.
    1. Structural Biology and Molecular Biophysics

    Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

    Oscar Vivas et al.
    Super-resolution imaging reveals a novel multi-channel arrangement that explains how big potassium (BK) channel activation closely tracks the opening of low-voltage-activated L-type calcium channels.
    1. Chromosomes and Gene Expression

    Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

    Hajnalka L Pálinkás et al.
    Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
    1. Cell Biology
    2. Developmental Biology

    bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring

    Vítor Trovisco et al.
    The localisation of bicoid mRNA depends on its microtubule-independent anchoring at the oocyte anterior.
    1. Cell Biology

    E-cadherin binds to desmoglein to facilitate desmosome assembly

    Omer Shafraz et al.
    Two critical events initiate and promote efficient desmosome assembly: stable binding of opposing E-cadherin cell-cell adhesion proteins; and direct interaction of E-cadherin and Desmoglein.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

    Li Li et al.
    Live imaging captures dynamics of Huntingtin aggregates plaguing the genome and waylaying target search.