49 results found
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    In situ cryo-ET structure of phycobilisome–photosystem II supercomplex from red alga

    Meijing Li et al.
    The nature of the phycobilisome–photosystem II supercomplex on the native thylakoid determined with cryo-electron tomography at an unprecedented resolution reveals that one phycobilisome interconnects with six photosystem monomers.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

    William F Richter et al.
    FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
    1. Cell Biology

    Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

    Maxence Le Vasseur et al.
    OCIAD1 associates with prohibitin assemblies and regulates the proteolytic processing and stability of the catalytical Complex III subunit cytochrome c1.
    1. Biochemistry and Chemical Biology

    Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

    Hongki Song et al.
    Sec18(NSF) and Sec17(αSNAP) provide a parallel pathway to fusion that is independent of energy from SNARE zippering.
    1. Plant Biology

    A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

    Rosa Pipitone et al.
    Serial-Block-Face Scanning Electron Microscopy (SBF-SEM) associated with biomolecular analysis show that chloroplast differentiation proceeds by distinct ‘structure establishment’ and ‘chloroplast proliferation’ phases, each with differential protein and lipid regulation.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Enzymes: The two roles of complex III in plants

    Hans-Peter Braun
    Atomic structures of mitochondrial enzyme complexes in plants are shedding light on their multiple functions.
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    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants

    Maria Maldonado et al.
    The structures of plant CIII2, CIV, and SC III2+IV challenge long-standing assumptions, generate new mechanistic hypotheses and allow for the generation of more selective agricultural inhibitors.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Plant Biology

    Photosynthesis without β-carotene

    Pengqi Xu et al.
    Tobacco plants containing xanthophyll astaxanthin show that both photosystems are fully functional in the absence of carotenes, and these pigments are not essential for photosynthesis.
    1. Cancer Biology

    Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

    Chun-Chun Cheng et al.
    The cancer testis antigen COX6B2 enhances cytochrome c oxidase activity thereby promoting proliferation and survival in cancer cells and represents a therapeutic target for inhibiting oxidative phosphorylation selectively in tumors.

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