89 results found
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondrial temperature homeostasis resists external metabolic stresses

    Mügen Terzioglu, Kristo Veeroja ... Howard T Jacobs
    Based on two independent methods, mitochondria operate at temperatures up to 15°C hotter than ambient, adjusting their heat production so as to maintain temperature in face of physiological stresses.
    1. Neuroscience

    Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

    Sébastien Houy, Alexander J Groffen ... Jakob Balslev Sørensen
    Doc2B functions in two distinct vesicle priming steps; membrane localization occludes upstream Ca2+-dependent priming, whereas Ca2+-binding and interaction with synaptotagmin-1, SNAREs, and Munc13-2 are involved in downstream priming, which makes vesicles readily releasable.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

    Myeongjune Jeon, Goowon Jeong ... Ilha Lee
    CBFs, the central regulators of low-temperature signaling, have a function to directly activate the expression of COOLAIR, an antisense RNA of FLC, during vernalization process, but COOLAIR is not required for the vernalization response.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Limitations to photosynthesis by proton motive force-induced photosystem II photodamage

    Geoffry A Davis, Atsuko Kanazawa ... David M Kramer
    Storage of solar energy in the thylakoid electrical field by photosynthesis in vivo can substantially destabilize charge-separated states in photosystem II, leading to singlet oxygen production and photodamage, contributing to loss of productivity, especially under fluctuating light experienced in the field.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested
    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.
    1. Structural Biology and Molecular Biophysics

    Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state

    Abhilash Padavannil, Anjaneyulu Murari ... James A Letts
    Molecular structure of mitochondrial complex I from Drosophila melanogaster reveals a structural element not seen in other organisms to date that may regulate the transition between an off-pathway resting state and the active state of the complex.
    1. Cell Biology

    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

    Enrico Radaelli, Charles-Antoine Assenmacher ... Marco Spinazzi
    Mitochondrial functional and structural defects caused by PARL deficiency lead to arrested spermatogenesis and germ cell ferroptosis.
    1. Cell Biology
    2. Neuroscience

    The SNAP-25 linker supports fusion intermediates by local lipid interactions

    Ahmed Shaaban, Madhurima Dhara ... Ralf Mohrmann
    The SNAP-25 linker acts as a functional component of SNARE complexes, initially facilitating SNARE interactions and later promoting fusion triggering and pore evolution by local membrane contacts.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji
    Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.

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