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    1. Neuroscience

    Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

    Steven A Hill et al.
    Astrocytes modulate synaptic remodeling of developing circuits in a cell type-specific manner, with long lasting deficits in synaptic plasticity.
    1. Neuroscience

    Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

    Narendra Mukherjee et al.
    Primary taste cortex does far more than code tastes by turning taste codes into motor commands via population dynamics.
    1. Neuroscience

    State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

    Amanda M Willard et al.
    The transition in basal ganglia output from the healthy to the diseased state is biphasic, stereotyped across models, and suggests key time points for delivering therapeutic interventions.
    1. Neuroscience

    Rapid task-dependent tuning of the mouse olfactory bulb

    Anzhelika Koldaeva et al.
    Sensory representation in the primary olfactory area is rapidly modulated when mice switch between easy and difficult discrimination tasks, optimising the sensory representation for the task at hand.
    1. Neuroscience

    Aquaporin-4-dependent glymphatic solute transport in the rodent brain

    Humberto Mestre et al.
    An international collaboration between five independent research groups replicates findings confirming the importance of aquaporin-4 in glymphatic solute transport using five different mouse knockout lines.
    1. Neuroscience

    The roles of vision and antennal mechanoreception in hawkmoth flight control

    Ajinkya Dahake et al.
    Mechanosensors in the antennae of hawkmoths provide rapid sensory feedback for the control of fast flight manoeuvres, which acts in parallel to visual information.
    1. Chromosomes and Gene Expression

    Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

    Jiyu Wang et al.
    An eukaryotic specific system cooperates with the ribosome quality control pathway to maintain the reading frame during translation of slowly translated sequences.
  1. Community first: An evolution in the approach to open publishing infrastructure with Libero

    Paul Shannon, Head of Technology, shares highlights from eLife’s journey in creating the Libero community.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The Aquilegia genome provides insight into adaptive radiation and reveals an extraordinarily polymorphic chromosome with a unique history

    Danièle L Filiault et al.
    The evolution columbine genus involved frequent mixing between incipient species, and one chromosome appears to have taken its own path.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

    Kevin D'hoe et al.
    Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.