65 results found
  1. Announcing the next phase of Executable Research Articles

    eLife and Stencila renew their partnership to make Executable Research Articles accessible to even more researchers and publishers.
  2. Community first: An evolution in the approach to open publishing infrastructure with Libero

    Paul Shannon, Head of Technology, shares highlights from eLife’s journey in creating the Libero community.
    1. Computational and Systems Biology

    Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species

    Arnaud Belcour et al.
    Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

    Katherine T Best et al.
    Adult Scleraxis-lineage cells are not required for successful tendon healing but are required for maintenance of tendon homeostasis.
    1. Structural Biology and Molecular Biophysics

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Johannes Thomsen et al.
    An open-source user-friendly toolbox implementing machine learning for single-molecule FRET analysis enabling experts and non-experts to reproducibly provide dynamic structural biology insights.
    1. Cancer Biology
    2. Genetics and Genomics

    Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

    Iris E Glykofridis et al.
    Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
    1. Genetics and Genomics
    2. Neuroscience

    An adipokine feedback regulating diurnal food intake rhythms in mice

    Anthony H Tsang et al.
    Adiponectin signaling integrates metabolic state information to regulate circadian clock function in hypothalamic appetite regulating centers, food intake rhythms, and body weight.
    1. Neuroscience

    Learning-related population dynamics in the auditory thalamus

    Ariel Gilad et al.
    The auditory thalamus encodes higher-order information that emerges while learning an auditory discrimination task.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Optical estimation of absolute membrane potential using fluorescence lifetime imaging

    Julia R Lazzari-Dean et al.
    Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

    James Chen et al.
    Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.

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