6,016 results found
    1. Structural Biology and Molecular Biophysics

    A label-free approach to detect ligand binding to cell surface proteins in real time

    Verena Burtscher et al.
    Binding of a charged small molecule to a membrane protein changes the amplitude of the apparent membrane capacitance by changing the charge density at the surfaces of the membrane.
    1. Biochemistry and Chemical Biology

    Ribosome surface properties may impose limits on the nature of the cytoplasmic proteome

    Paul E Schavemaker et al.
    The diffusion coefficients of proteins in the cytoplasm depend on their net charge and the distribution of charge over the protein surface, with positive proteins moving up to 100-fold slower because they bind to ribosomes.
    1. Neuroscience

    Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

    Briana J Martiszus et al.
    External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Structural Biology and Molecular Biophysics

    Phosphatidic acid modulation of Kv channel voltage sensor function

    Richard K Hite et al.
    Phosphatidic acid influences the gating of voltage-gated K+ channels through a non-specific surface charge mechanism and through a specific interaction between a voltage sensor arginine and the primary phosphate head group on the cytoplasmic membrane leaflet.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

    Sudeep Banjade et al.
    ESCRT-III heteropolymers utilize non-specific lateral electrostatic interactions to recognize one another, which may enable the polymers to slide along one another and adapt to different curvatures.
    1. Ecology

    Acoustic shadows help gleaning bats find prey, but may be defeated by prey acoustic camouflage on rough surfaces

    Elizabeth L Clare, Marc W Holderied
    Some species of bats hunt for insects that are resting on surfaces by detecting interruptions in the echoes from that surface, suggesting that resting on rough surfaces may help insects to evade detection by echolocation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

    Bettina Wurzer et al.
    Oligomerization of p62/SQSTM1 generates high avidity binding regions that enable it to spatially select for concentrated ubiquitin and ATG8-family proteins.
    1. Evolutionary Biology

    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

    Kai He et al.
    Ancestral sequence reconstruction of an essential muscle protein involved in oxygen storage and transport accurately tracks secondary aquatic transitions in a speciose clade of insectivorous mammals.
    1. Structural Biology and Molecular Biophysics

    Contacts-based prediction of binding affinity in protein–protein complexes

    Anna Vangone, Alexandre MJJ Bonvin
    The number of contacts at the interface of a protein–protein complex, together with the properties of the surface, provides a simple, but well-performing predictor of binding affinity.

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