205 results found
    1. Immunology and Inflammation

    Kidins220 regulates the development of B cells bearing the λ light chain

    Anna-Maria Schaffer, Gina Jasmin Fiala ... Susana Minguet
    The scaffold protein Kidins220 regulates the development of λLC B cells by supporting B cell precursor survival and optimizing pre‑BCR and BCR signaling.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings, Komal Makwana ... Emma S Lucas
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray, Zane N Aldworth, Mark A Stopfer
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Neuroscience

    Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms

    Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    Interrogating theoretical models of neural computation with emergent property inference

    Sean R Bittner, Agostina Palmigiano ... John Cunningham
    Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.
    1. Developmental Biology
    2. Evolutionary Biology

    Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

    Juan Jose Fraire-Zamora, Johannes Jaeger, Jérôme Solon
    Evolutionary reduction in tissue number involves the simplification of the seaming process but not signaling during epithelial fusion.
    1. Neuroscience

    Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

    Sören J Zapp, Mohammad H Khani ... Tim Gollisch
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Plant Biology

    Root-specific theanine metabolism and regulation at the single-cell level in tea plants (Camellia sinensis)

    Shijia Lin, Yiwen Zhang ... Zhaoliang Zhang
    A single-cell RNA sequencing reveals cell heterogeneity of secondary metabolism in tea plant root and a proposed model in which the theanine biosynthesis pathway occurs via multicellular compartmentation.
    1. Developmental Biology
    2. Plant Biology

    Cell type boundaries organize plant development

    Monica Pia Caggiano, Xiulian Yu ... Marcus G Heisler
    Leaf position, shape and orientation are pre-patterned by cell type boundaries in the shoot meristem.

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