7,338 results found
    1. Ecology
    2. Evolutionary Biology

    Intergenerational effects of early adversity on survival in wild baboons

    Matthew N Zipple, Elizabeth A Archie ... Susan C Alberts
    In wild baboons, a female's adverse early experiences can influence her offspring's survival years after the original adversity was experienced.
    1. Developmental Biology
    2. Neuroscience

    Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

    Ryoji Amamoto, Grace K Wallick, Constance L Cepko
    Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration.
    1. Biochemistry and Chemical Biology

    Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

    Holly Y Chen, Manju Swaroop ... Anand Swaroop
    High-throughput screening of over 6000 drugs using cells and retina tissue with a CEP290 ciliopathy mutation identified a small molecule, reserpine, which enhanced photoreceptor survival in retinal organoids and in a mouse disease model by partially restoring balance in proteostasis.
    1. Cancer Biology

    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

    Pirunthan Perampalam, James I MacDonald ... Frederick A Dick
    Extending the period of remission for cancer patients requires new knowledge of dormant, residual disease and Netrin signaling contributes to the survival of dormant cells in ovarian cancer.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global divergence in critical income for adult and childhood survival: analyses of mortality using Michaelis–Menten

    Ryan J Hum, Prabhat Jha ... Yu-Ling Cheng
    A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
    1. Cancer Biology
    2. Cell Biology

    A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

    Jesusa Capera, Mireia Pérez-Verdaguer ... Antonio Felipe
    The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.
    1. Cell Biology
    2. Developmental Biology

    CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

    Austin Xun Ding, Gongping Sun ... Denise J Montell
    Genetic labeling of cells that survive executioner caspase activity in Drosophila reveals distinct patterns in different tissues.
    1. Physics of Living Systems

    Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome

    Sae-Il Murtada, Nicole Mikush ... Jay D Humphrey
    Daily administration of the farnesyltransferase inhibitor lonafarnib decreases central artery stiffness, increases distal artery vasoactivity, and improves left ventricular function consistent with increased survival in a mouse model of Hutchinson-Gilford progeria syndrome.
    1. Developmental Biology
    2. Neuroscience

    Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

    Eleni Kougioumtzidou, Takahiro Shimizu ... William D Richardson
    Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.
    1. Neuroscience

    Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

    Christina Chatzi, Eric Schnell, Gary L Westbrook
    Neural progenitors reside in relative low oxygen in the subgranular zone (SGZ), and the higher tissue oxygen levels that these cells must face as they migrate away from the hypoxic areas and differentiate appear to cause oxidative damage and an early phase of cell death.

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