Jolle Wolter Jolles, Matthew MG Sosna ... Iain D Couzin
Detailed tracking of live predators attacking live schools of prey reveals the crucial interplay between predator attack strategy and prey behaviour and positioning in determining the predation risk within mobile animal groups.
Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.
Laura Whitworth, Jacob Coxon ... Lalita Ramakrishnan
In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
Nicolai J Toft, Trine V Axelsen ... Ebbe Boedtkjer
Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.
Loss of the RNA-binding protein TDP-43 impairs the survival of oligodendrocyte progenitors and reactivates growth of mature oligodendrocytes, resulting in inappropriate wrapping of neuronal somata and blood vessels.
Sarah Rose Anderson, Jacqueline M Roberts ... Monica L Vetter
In postnatal retina, neuronal apoptosis promotes a spectrum of microglial transcriptional states with varied dependence on CSF1R; TAM receptor Mer and complement receptor 3 mediate phagocytosis of dying neurons while altered CSF1R dependence requires Axl.
Daniel J Laydon, Ilaria Dorigatti ... Neil M Ferguson
Bayesian survival analysis reveals comprehensive efficacy profile and mechanism of action for Sanofi-Pasteur’s CYD-TDV dengue vaccine, whereby vaccination acts as a silent, disease-free infection enhancing disease risk in seronegatives, but giving greater immunity in seropositives than two natural infections.
Jonathan D Hibshman, Alexander E Doan ... L Ryan Baugh
daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.
David Duneau, Jean-Baptiste Ferdy ... Nicolas Buchon
An analysis of within-host bacterial proliferation reveals that minor "stochastic" variation in the ability of the innate immune response to control bacterial growth early on can result in either survival or death of the host.
The oncogenic potential of the serine threonine kinase AKT is not exclusively dependent on catalytic activity, but also involves the non-catalytic function of the pleckstrin homology domain.
