79 results found
    1. Neuroscience

    A projectome of the bumblebee central complex

    Marcel Ethan Sayre et al.
    Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.
    1. Neuroscience

    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

    Jason D Vevea et al.
    Synaptotagmin 7 is asymmetrically localized to the axonal plasma membrane through γ-secretase processing to promote vesicle docking during short-term synaptic plasticity in mouse hippocampal neurons.
    1. Structural Biology and Molecular Biophysics

    Hsp40s play complementary roles in the prevention of tau amyloid formation

    Rose Irwin et al.
    Chaperones from different families and classes synergistically target different stages of tau aggregation, thus preventing pathological amyloid formation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden et al.
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.
    1. Neuroscience

    Ir56d-dependent fatty acid responses in Drosophila uncover taste discrimination between different classes of fatty acids

    Elizabeth B Brown et al.
    The taste system of fruit flies is activated by broad classes of fatty acids and can discriminate between different classes, revealing previously underappreciated complexity in the coding of tastants.
    1. Neuroscience

    Sniff-synchronized, gradient-guided olfactory search by freely moving mice

    Teresa M Findley et al.
    To track odors borne on turbulent airflow, mice strategically follow their nose, with sampling movements and sensory computations reminiscent of those demonstrated in nematodes and insects.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

    Rachel A Johnston et al.
    In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
    1. Neuroscience

    The connectome of the adult Drosophila mushroom body provides insights into function

    Feng Li et al.
    Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
    1. Neuroscience

    Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii

    Hany KM Dweck et al.
    The evolutionary transition of the agricultural pest Drosophila suzukii to egg laying on ripe fruits was paralleled with several gustatory innovations.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

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