234 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

    Ignacio Mena et al.
    Genome sequence data from 58 Mexican swine influenza A viruses resolves the spatial origin of the virus that originated the influenza pandemic of 2009.
    1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen et al.
    The abundance and complex genetic diversity of swIAV were documented and the zoonotic potential evaluated.
    1. Microbiology and Infectious Disease

    HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets

    Meng Hu et al.
    Infection experiments in ferrets reveal swine influenza viruses need their hemagglutinin antigen to become stabilized for transmissibility, adding a new property to consider when triaging field isolates for pandemic potential.
    1. Neuroscience

    Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

    Margarita C Dinamarca et al.
    A protein called RNF10 relays messages from synapses to neuron cell nuclei, and is responsible for long-lasting modifications of dendritic spines as observed after activation of synaptic glutamate receptors.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso et al.
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew et al.
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Mapping influenza transmission in the ferret model to transmission in humans

    Michael G Buhnerkempe et al.
    Influenza transmission among ferrets correlates strongly with transmission among humans, so the ferret model for influenza transmission is a valid tool for pandemic potential in humans.
    1. Neuroscience

    Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease

    Niklas Schwarz et al.
    Viral transduction and gene manipulation of adult human brain slices will be of great value allowing investigations including therapeutic screening, electrophysiological and structural studies of properties of human CNS circuitry.
    1. Epidemiology and Global Health

    The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

    Katia Koelle, David A Rasmussen
    Deleterious mutations slow down flu's antigenic evolution, make it more punctuated in nature, and reduce the virus's genetic diversity.

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