Prefrontal causal roles in bistable perception are dynamically changing and determined by the brain state to which the whole-brain activity pattern belongs.
A computer model of the mouse visual cortex shows that local brain circuits are organized as switches whose states are coded as neuronal oscillations with different frequencies.
Cecilia Lövkvist, Pawel Mikulski ... Martin Howard
Extra protein memory storage elements with positive feedbacks, in addition to histone modifications, can explain epigenetic switching and memory at the PRC2 target gene FLOWERING LOCUS C (FLC).
Nigel J Burroughs, Edward F Harry, Andrew D McAinsh
Directional switching of sister chromatids during mitosis is regulated by a mechanical clock that is sensitive to the stretch of centromeric chromatin between the chromatids.
By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
Rebecca Devlin, Catarina A Marques ... Richard McCulloch
Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.
Hamdah Shafqat-Abbasi, Jacob M Kowalewski ... Staffan Strömblad
“Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
Asymmetric forward and backward swimming speeds reveal that the rotational bias, and not reversal frequencies, is an appropriate measure of chemotaxis signaling in Helicobacter pylori..