1,448 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

    Daniel Elnatan et al.
    A flip of the dimer asymmetry following the first ATP hydrolysis provides a mechanistic model for client remodeling by the mitochondrial Hsp90, TRAP1.
    1. Physics of Living Systems

    Active torque generation by the actomyosin cell cortex drives left–right symmetry breaking

    Sundar Ram Naganathan et al.
    The actomyosin cytoskeleton generates active chiral torques that lead to left-right asymmetry in C. elegans embryos.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Developmental Biology
    2. Neuroscience

    Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry

    Ingrid Lekk et al.
    The sox1a gene is required for a small group on neurons on the left side of the brain to influence the generation and left-sided character of their future synaptic partners.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Symmetry breaking in reconstituted actin cortices

    Enas Abu Shah, Kinneret Keren
    A reconstituted system has been developed that self-organizes into dynamic actin cortices capable of spontaneous polarization, similar to the initial cortical polarization observed in cells during embryogenesis and development.
    1. Developmental Biology

    Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

    Almary Guerra et al.
    A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
    1. Developmental Biology

    TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish

    Jonathan Fillatre et al.
    Transcription factors downstream of Hippo signaling control formation of the Left-Right Organizer by regulating major signaling pathways, expression of transcription factors and regulators of epigenetic programming involved in this process.
    1. Cell Biology
    2. Developmental Biology

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Structural Biology and Molecular Biophysics

    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

    Lejla Zubcevic et al.
    Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.
    1. Structural Biology and Molecular Biophysics

    Functional asymmetry and electron flow in the bovine respirasome

    Joana S Sousa et al.
    Cryo-EM structure of the mammalian respiratory supercomplex containing complexes I, III and IV shows a functional asymmetry of complex III, providing strong evidence for directed electron flow in the respirasome.

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