134 results found
    1. Cancer Biology
    2. Neuroscience

    Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

    Susu Pan et al.
    Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Neuroscience

    Bayesian inference of population prevalence

    Robin AA Ince et al.
    Bayesian estimation of the proportion of the population that would show an effect in an experiment provides a broadly applicable alternative to standard null hypothesis tests on the population mean with several advantages.
    1. Neuroscience

    Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

    Ella Podvalny et al.
    Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.
    1. Neuroscience

    Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

    Oshri Avraham et al.
    The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
    1. Neuroscience

    Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

    Filip Sobczak et al.
    The variability of the pupil–fMRI relationship was characterized through a combination of clustering and prediction methods, which revealed brain state-specific subcortical and neuromodulatory activation patterns reflected in pupil dynamics.
    1. Medicine
    2. Neuroscience

    Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

    Xiao Lv et al.
    PGE2/EP4 skeleton interoception regulates bone and fat metabolism via hypothalamic NPY.
    1. Structural Biology and Molecular Biophysics

    The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

    Vivek Garg et al.
    A comprehensive functional analysis of mitochondrial Ca2+ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca2+ transport via MCU.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

    Corbin SC Johnson et al.
    Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.
    1. Neuroscience

    The severity of microstrokes depends on local vascular topology and baseline perfusion

    Franca Schmid et al.
    The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.

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