833 results found
    1. Neuroscience

    Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

    Junhua Yang et al.
    Astrocytes regulate the pruning of excitatory synapses during early life through ATP signaling.
    1. Neuroscience

    Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice

    Shu-Hsien Sheu et al.
    A similar pattern of developmental synaptic refinement leads two consecutive synaptic relays to have the same organization suggesting that some general principle of neural organization is at play.
    1. Neuroscience

    Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

    Chia-Wei Chang et al.
    Increasing periods of neuronal activity progressively weaken and then eliminate synapses through the activation of specific transcription factors and genes.
    1. Neuroscience

    The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

    Ronen Reshef et al.
    During adult neurogenesis in the olfactory bulb, microglia regulate the elimination (pruning), formation, and maintenance of synapses on newborn neurons, contributing to the functional integrity of the olfactory bulb circuitry.
    1. Neuroscience

    The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

    Tyne W Miller-Fleming et al.
    The protein UNC-8 is a neuronal activity sensor that triggers the elimination of synapses during development of the nervous system.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen et al.
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Neuroscience

    An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

    Silke Frahm et al.
    Local elimination of acetylcholine synthesis in habenular neurons demonstrates a key role for vesicular synergy and neurotransmitter co-release in nicotine dependence.
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang et al.
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Developmental Biology
    2. Neuroscience

    Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function

    Dimitar Kostadinov, Joshua R Sanes
    Patterning of dendrites by protocadherin-dependent self-avoidance and self/non-self discrimination is required for proper function of a retinal circuit that computes the direction of motion.
    1. Neuroscience

    Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

    Dorothy P Schafer et al.
    In mouse models of Rett Syndrome, global loss of the Mecp2 gene induces microglia to engulf excess synapses, while microglia-specific loss or gain of Mecp2 has little impact on disease.

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