1,311 results found
    1. Neuroscience

    Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

    Kevin Dorgans et al.
    Molecular, structural and functional diversity of cerebellar granule cell inputs on single molecular layer interneurons extends information processing in feed-forward inhibition microcircuits.
    1. Developmental Biology
    2. Neuroscience

    Regulation of subcellular dendritic synapse specificity by axon guidance cues

    Emily C Sales et al.
    Axon guidance cues restrict sensory neuron synapse formation to a subset of equally acceptable interneuronal dendritic arbors during Drosophila locomotor circuit assembly.
    1. Neuroscience

    LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

    Alessandra Sclip, Thomas C Südhof
    LAR-RPTPs are not essential for synapse formation, but they are important determinants of synapse properties as they contribute to regulate postsynaptic NMDA receptor function.
    1. Cell Biology
    2. Neuroscience

    Aberrant information transfer interferes with functional axon regeneration

    Chen Ding, Marc Hammarlund
    Defects in synapse regeneration limit functional circuit recovery after nerve injury by misdirecting information via ectopic dendritic synapses, and also by functional and molecular deficits in reformed axonal synapses.
    1. Cell Biology
    2. Immunology and Inflammation

    Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

    Madison Bolger-Munro et al.
    Arp2/3 complex-mediated actin polymerization shapes how B lymphocytes probe the surface of antigen-presenting cells, promotes coalescence of B cell receptor (BCR) microclusters, amplifies BCR signaling, and enhances B cell activation.
    1. Developmental Biology
    2. Neuroscience

    Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

    Andre Voelzmann et al.
    A novel regulatory cascade downstream of Tau and spectraplakins ensures that synaptic proteins are delivered to axonal terminals in the developing and ageing brain, providing potential explanations for precocious synapse loss in dementias.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

    Misty R Jenkins et al.
    Inhibition of the catalytic activity of the Zap70 kinase reveals that discrete TCR-regulated events control the remodelling of the actin cytoskeleton when the cytotoxic T cell interacts with its target.
    1. Neuroscience

    Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

    Xi Chen et al.
    Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
    1. Neuroscience

    Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells

    Liyi Li et al.
    Young neurons of the adult hippocampus are synaptically activated by a small group of non-overlapping afferent excitatory fibers, due to high synaptic gain and sparse connectivity, important for sparse and orthogonal coding during hippocampal information processing.
    1. Neuroscience

    Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development

    Mehmet Neset Özel et al.
    Long-term live imaging in intact developing Drosophila brains reveals a role for N-Cadherin-mediated fast filopodial dynamics and growth cone stabilization during neural circuit assembly.

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