208 results found
    1. Neuroscience

    Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum

    Roger Shen Zhang, Kif Liakath-Ali, Thomas C Südhof
    Knockout of both latrophilin-2 and latrophilin-3 from Purkinje cells in mice selectively impairs parallel-fiber synapses, revealing a redundant but critical function for latrophilins at specific synapses.
    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina, Jane Wang ... Kota Mizumoto
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg, Romain Brette, Dan FM Goodman
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Computational and Systems Biology
    2. Neuroscience

    BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

    Chaoming Wang, Tianqiu Zhang ... Si Wu
    BrainPy presents a general-purpose programming framework that enables efficient implementation, simulation, training, and analysis of brain dynamics models across multiple organization scales, ultimately facilitating the understanding of the complex neural mechanisms underlying brain functions.
    1. Neuroscience

    Specific Neuroligin3–αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus

    Motokazu Uchigashima, Kohtarou Konno ... Kensuke Futai
    Trans-synaptic protein interactions are required for synapse specification and function, and the combination between neuroligin3 and αneurexin1 controls inhibitory synaptic function in a splice isoform- and interneuron-specific manner.
    1. Developmental Biology
    2. Neuroscience

    Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

    Lei Xing, Rylan S Larsen ... Jason M Newbern
    Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar, Tingkai Liu ... Yiyin Zhou
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Neuroscience

    Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans

    Lingfeng Meng, Albert Zhang ... Dong Yan
    Genetic study of C. elegans neural development reveals the function of glia-neuron gap junctions in neuronal axon specification, and shows that glial cells regulate neuronal intracellular pathways through gap junctions.
    1. Developmental Biology
    2. Neuroscience

    Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

    Catarina Catela, Yihan Chen ... Paschalis Kratsios
    Molecular, genetic, and behavioral assays in mice establish a new role for Hox proteins in the final steps of spinal motor neuron development.
    1. Computational and Systems Biology
    2. Neuroscience

    NetPyNE, a tool for data-driven multiscale modeling of brain circuits

    Salvador Dura-Bernal, Benjamin A Suter ... William W Lytton
    The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.

Refine your results by:

Type
Research categories