751 results found
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Neuroscience

    SynEM, automated synapse detection for connectomics

    Benedikt Staffler et al.
    The detection of chemical synapses in 3-dimensional electron microscopy data has been automated such that synapses in large-scale connectivity maps of the cerebral cortex, connectomes, can be charted without the need for human interaction.
    1. Neuroscience

    Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons

    Timothy J Mosca et al.
    The cell surface receptor LRP4, long recognized for postsynaptic functions, also plays a role as a presynaptic determinant of synapse formation by functioning through a downstream kinase pathway.
    1. Cell Biology
    2. Immunology

    Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

    Catherine A Hartzell et al.
    By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu et al.
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

    Andre Voelzmann et al.
    A novel regulatory cascade downstream of Tau and spectraplakins ensures that synaptic proteins are delivered to axonal terminals in the developing and ageing brain, providing potential explanations for precocious synapse loss in dementias.
    1. Neuroscience

    Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

    Chia-Wei Chang et al.
    Increasing periods of neuronal activity progressively weaken and then eliminate synapses through the activation of specific transcription factors and genes.
    1. Neuroscience

    Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

    Nicholas P Vyleta et al.
    Activity-dependent enhancement of transmitter release makes the hippocampal mossy fiber synapse a full detonator in rats.
    1. Neuroscience

    Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses

    Quynh-Anh Nguyen et al.
    Electrophysiological recordings reveal domains within the extracellular and intracellular region of neuroligin important for specifying and carrying out its function at inhibitory synapses respectively.
    1. Neuroscience

    Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses

    Gordon X Wang et al.
    The development of a novel, high throughput method for the sub-synaptic analysis of protein localization in molecularly classified synapse classes allows sub-compartment, multiplexed detection of proteins in synapses using wide-field microscopes.

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