Browse the search results

Page 2 of 99
    1. Neuroscience

    Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

    Chia-Wei Chang et al.
    Increasing periods of neuronal activity progressively weaken and then eliminate synapses through the activation of specific transcription factors and genes.
    1. Neuroscience

    A genetic basis for molecular asymmetry at vertebrate electrical synapses

    Adam C Miller et al.
    Electrical synapses are neuronal, gap-junction-based connections found throughout the nervous system that, in the escape circuit of zebrafish, are composed of molecularly distinct pre- and postsynaptic junction forming proteins that are required for behavioral performance.
    1. Neuroscience

    Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

    Joana S Ferreira et al.
    D-serine has a major role in the regulation of NMDA receptors not only contributing to its activation as the receptors co-agonist, but also by regulating specifically GluN2B-NMDA receptor trafficking and synaptic content at developing hippocampal synapses.
    1. Neuroscience

    Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses

    Quynh-Anh Nguyen et al.
    Electrophysiological recordings reveal domains within the extracellular and intracellular region of neuroligin important for specifying and carrying out its function at inhibitory synapses respectively.
    1. Neuroscience

    Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses

    Gordon X Wang et al.
    The development of a novel, high throughput method for the sub-synaptic analysis of protein localization in molecularly classified synapse classes allows sub-compartment, multiplexed detection of proteins in synapses using wide-field microscopes.
    1. Neuroscience

    Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

    Nicholas P Vyleta et al.
    Activity-dependent enhancement of transmitter release makes the hippocampal mossy fiber synapse a full detonator in rats.
    1. Neuroscience

    Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

    Junhua Yang et al.
    Astrocytes regulate the pruning of excitatory synapses during early life through ATP signaling.
    1. Neuroscience

    Nanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse

    Itaru Arai, Peter Jonas
    Ca2+ channels and release sensors at a fast central synapse are tightly coupled, which minimizes the effect of extracellular Ca2+ concentration on the timing of transmitter release.
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang et al.
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Neuroscience

    Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice

    Shu-Hsien Sheu et al.
    A similar pattern of developmental synaptic refinement leads two consecutive synaptic relays to have the same organization suggesting that some general principle of neural organization is at play.