1,477 results found
    1. Developmental Biology

    Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    The homeodomain protein Bsh increases lamina neuron types and visual function.
    1. Neuroscience

    Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

    Yi-jun Zhu, Cai-yun Deng ... Hua-tai Xu
    For neurons to prevent undesirable synaptic connections in the brain, the combinatorial expression of γ-PCDH is essential.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook, Shankar Ramachandran ... Michael M Francis
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
    1. Neuroscience

    Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation

    Travis A Hage, Alice Bosma-Moody ... Gabe J Murphy
    A combination of multicellular recording and optogenetic photostimulation was used to deeply characterize the spatial profiles and effective strengths of intralaminar and translaminar synaptic connections from genetically defined neuronal populations in the visual cortex of adult mouse.
    1. Neuroscience

    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

    Mean-Hwan Kim, Cristina Radaelli ... Ed Lein
    Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on their subclass interneuron identity.
    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Neuroscience

    Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior

    Emily A Bayer, Rebecca C Stecky ... Oliver Hobert
    The sex-specificity of a transcription factor required for sexual differentiation of a neural circuit is regulated by a novel post-transcriptional mechanism.
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Neuroscience

    Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex

    Antoine M Valera, Francesca Binda ... Philippe Isope
    Functional synaptic organization in the cerebellar cortex is stereotyped and associates distant modules through parallel fibers.

Refine your results by:

Type
Research categories