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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

    Tarik Seref Onur et al.
    Cross-species transcriptomic analysis and high-throughput behavioral assays in a Drosophila model of Huntington's disease show that downregulation of glial genes involved in synaptic function compensates for disease-related excitotoxicity.
    1. Cell Biology
    2. Neuroscience

    Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

    Guanglin Xing et al.
    Neurexin–Neuroligin1 complex positively regulates F-actin assembly through direct interaction with WAVE complex to control normal synaptic growth and electrophysiological function in Drosophila neuromuscular junction.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba et al.
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu et al.
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Cell Biology
    2. Developmental Biology

    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

    Alireza Ghasemizadeh et al.
    Maintenance of peripheral myonuclei patterning in skeletal myofibers is dependent on the regulation of microtubules dynamic and nuclei motion and is essential for proper neuromuscular junction integrity and mitochondria homeostasis.
    1. Cell Biology
    2. Neuroscience

    Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

    Hui Ye et al.
    Vps29 promotes retromer localization in the adult Drosophila brain, engaging Rab7 and TBC1D5, and its loss triggers age-dependent neuronal impairments in endolysosomal trafficking and synaptic transmission.
    1. Genetics and Genomics
    2. Neuroscience

    Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans

    Yung-Chi Huang et al.
    Caenorhabditis elegans studies indicate that gain-of-function mutations in the presynaptic voltage-gated calcium, associated with familial hemiplegic migraine in humans, result in excitatory-inhibitory imbalance in the nervous system.
    1. Neuroscience

    ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans

    Kelly H Oh et al.
    An endoplasmic reticulum membrane protein regulates synaptic transmission, alcohol sensitivity, and gene expression by controlling the trafficking of a calcium-activated potassium channel.
    1. Cell Biology
    2. Neuroscience

    Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

    Zhao Xuan et al.
    Clarinet, a novel C. elegans active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente et al.
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.