658 results found
    1. Neuroscience

    C. elegans neurons have functional dendritic spines

    Andrea Cuentas-Condori et al.
    Caenorhabditis elegans has bona fide dendritic spines, suggesting that the advantages of small model organisms, such as genetic manipulations and live-cell imaging, can be exploited to study dendritic spines.
    1. Neuroscience

    Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

    Christopher W Mount et al.
    Oligodendrocyte precursor cells receive brain-wide, circuit-specific intracortical, coritcocortical and thalamocortical synaptic inputs.
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser et al.
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg et al.
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Neuroscience

    A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

    Jie-Xian Dong et al.
    Nanobodies are developed that target neuronal proteins with restricted subcellular distributions and used as intrabodies to deliver cargo to specific sites within neurons and nanoscale immunolabels for improved imaging resolution.
    1. Neuroscience

    Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth

    Samora Okujeni, Ulrich Egert
    Activity-dependent neurite outgrowth and neuronal migration interact to shape modular mesoscale network architecture by homeostatic self-organization.
    1. Neuroscience
    2. Physics of Living Systems

    A geometric attractor mechanism for self-organization of entorhinal grid modules

    Louis Kang, Vijay Balasubramanian
    The hierarchy of entorhinal grid cell modules with constant scale ratios can self-organize through a new geometrically organized attractor mechanism.
    1. Neuroscience

    Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

    Míriam Javier-Torrent et al.
    EphA signaling plays dual opposite roles on axon dynamics in neurons, so it inhibits and promotes axon growth through ligand binding and receptor processing, respectively.
    1. Developmental Biology
    2. Neuroscience

    The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

    Alexander GJ Skorput et al.
    Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.
    1. Computational and Systems Biology
    2. Neuroscience

    Population adaptation in efficient balanced networks

    Gabrielle J Gutierrez, Sophie Denève
    Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.

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