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    1. Cell Biology
    2. Neuroscience

    The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

    Jie Gao et al.
    Control of lipoprotein receptor protein levels at synapses by the E3 ubiquitin ligase IDOL is shown to be important for the plasticity of neuronal dendrites in vitro and learning and memory in mice.
    1. Cell Biology
    2. Neuroscience

    Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines

    Sonia Afroz et al.
    Extrasynaptic GABAA receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni et al.
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar et al.
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Computational and Systems Biology
    2. Neuroscience

    T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

    Marcel Beining et al.
    T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
    1. Cell Biology
    2. Neuroscience

    An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis

    Steven J Del Signore et al.
    Autoinhibition allows synaptic endocytic actin regulators to pre-deploy to synaptic membranes at high concentrations and constrains actin assembly to productive events.
    1. Neuroscience

    Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

    Ying Wang et al.
    Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.
    1. Neuroscience

    Inferring circuit mechanisms from sparse neural recording and global perturbation in grid cells

    John Widloski et al.
    A novel experimental method and analysis is conceived, based on perturbation and sparse recording, to elucidate the circuit structure and mechanisms underlying the responses of grid cells.
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld et al.
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Neuroscience

    Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction

    Opeyemi O Alabi et al.
    Disruption of the disease-associated synaptic adhesion molecule Neurexin1a in cortical excitatory neurons perturbs decision making and disrupts value-associated neural activity in downstream striatal circuits.