Group III metabotropic glutamate receptor inhibition facilitates synaptic plasticity in the plasticity-resistant synapses of hippocampal area CA2, a brain region critical for social memory.

Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.

The metabolic efficiency of learning in networks is improved by using forms of synaptic plasticity with different levels of persistence.

Non-invasive transcutaneous electrical stimulation of the greater occipital nerve using direct current promotes strengthening of memories using late-phase synaptic activity.

In a mouse model of psychiatric illness, the neuronal network of the medial prefrontal cortex is characterized by reduced activity levels of interneurons, impaired gamma oscillations, and altered activation of cell assemblies.

The postsynaptic endocytic zone is a highly organized structure composed of a diversity of endocytic proteins.

Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.

Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.

The combination of juxtacellular recordings with optogenetics in freely moving mice enables the targeting of genetically defined cell classes for high-resolution, single-cell structure–function analysis.

New protein labeling strategies unravel the subcellular distribution of neurotransmitter receptor subunits and voltage-gated ion channels in motion-sensing T4/T5 neurons of the Drosophila visual system.