311 results found
    1. Neuroscience

    ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans

    Kelly H Oh et al.
    An endoplasmic reticulum membrane protein regulates synaptic transmission, alcohol sensitivity, and gene expression by controlling the trafficking of a calcium-activated potassium channel.
    1. Neuroscience

    Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1

    Nengyin Sheng et al.
    Auxiliary subunits Neto1 and Neto2 regulate the GluK1 receptor targeting to excitatory silent synapses through different molecular mechanisms and also modify receptor biophysics through distinct mechanisms.
    1. Cell Biology
    2. Neuroscience

    Synaptic activity regulates AMPA receptor trafficking through different recycling pathways

    Ning Zheng et al.
    There are at least two separate pathways for AMPA receptor recycling, which are regulated by synaptic activity.
    1. Cell Biology
    2. Neuroscience

    Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines

    Aaron B Bowen et al.
    Neurons use a non-canonical secretory network to deliver select proteins to postsynaptic sites in dendrites.
    1. Neuroscience

    Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

    Joana S Ferreira et al.
    D-serine has a major role in the regulation of NMDA receptors not only contributing to its activation as the receptors co-agonist, but also by regulating specifically GluN2B-NMDA receptor trafficking and synaptic content at developing hippocampal synapses.
    1. Neuroscience

    Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

    Thirumalini Vaithianathan et al.
    A combination of tethered diffusion of release-ready synaptic vesicles and vesicle-vesicle fusion supports neurotransmitter release at the presynaptic active zone of sensory synapses.
    1. Neuroscience

    The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

    Yongchao Han et al.
    BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Neuroscience

    The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

    Leanne J M Schmitz et al.
    Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of hippocampal AMPARs, and is necessary for synaptic plasticity and memory recall.
    1. Neuroscience

    A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism

    Elliot Imler et al.
    Genetic analysis of a CLN4 Drosophila model suggests that the disease-causing alleles act as dominant gain of function mutations that cause CSPα oligomerization and impair secretory and prelysosomal trafficking.
    1. Computational and Systems Biology
    2. Neuroscience

    Dendritic trafficking faces physiologically critical speed-precision tradeoffs

    Alex H Williams et al.
    A simple model of active transport in neurons allows intracellular cargo to find sites of demand using only local signals, but predicts long delays in distributing cargo throughout a dendritic tree.

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