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    1. Developmental Biology
    2. Genetics and Genomics

    Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

    Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
    Modelling O-GlcNAc transferase intellectual disability reveals the roles of this post-translational modification in regulating normal axonal terminal morphology and maintaining appropriate sleep homeostasis, pharmacological and genetic rescues of O-GlcNAcylation highlight the complexities of addressing this disorder.
    1. Developmental Biology

    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

    Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

    Dena Goldblatt, Basak Rosti ... David Schoppik
    An analysis of vestibular projection neurons lacking their motor neuron partners resolves outstanding controversies for whether and how motor neurons shape vestibulo-ocular reflex circuit assembly.
    1. Evolutionary Biology

    Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity

    William R Thomas, Troy Richter ... Liliana M Dávalos
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury

    Qing Zhao, Yanjing Zhu ... Ning Xie
    Selectively eliminating resident astrocytes in lumbar enlargement attenuated neuropathic pain associated with type I interferons (IFNs) signal activation in microglia.
    1. Neuroscience

    Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

    Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

    Xue Chen, Deng Pan ... Yanrui Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

    J Wesley Maddox, Gregory J Ordemann ... Amy Lee
    In congenital stationary night blindness type 2, Cav3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Cav1.4 in cone synaptogenesis remains intact.
    1. Neuroscience

    Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range

    Pál Barzó, Ildikó Szöts ... Gábor Tamás
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
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