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    1. Cell Biology
    2. Neuroscience

    Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs

    Zora Chui-Kuen Chan, Hiu-Lam Rachel Kwan ... Chi Wai Lee
    Postsynaptic MT1-MMP serves as a molecular switch to synaptogenesis by clearing the surrounding ECM environment that allows effective deposition of nerve-derived synaptogenic factors to induce postsynaptic differentiation at developing NMJs.
    1. Developmental Biology
    2. Neuroscience

    R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

    Jessica Douthit, Ariel Hairston ... Jessica E Treisman
    R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.
    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang, William C Spencer ... Evan S Deneris
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.
    1. Developmental Biology
    2. Neuroscience

    Cadherins regulate nuclear topography and function of developing ocular motor circuitry

    Athene Knüfer, Giovanni Diana ... Sarah Guthrie
    Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.
    1. Developmental Biology
    2. Neuroscience

    Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

    Agnik Dasgupta, Caleb C Reagor ... AJ Hudspeth
    Semaphorin7A sculpts the collective arbor architecture of the lateral line nerve and facilitates neural contacts with the hair cells for synaptogenesis during neuromast development in the zebrafish.
    1. Neuroscience

    A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

    J Wesley Maddox, Gregory J Ordemann ... Amy Lee
    In congenital stationary night blindness type 2, Cav3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Cav1.4 in cone synaptogenesis remains intact.
    1. Developmental Biology

    Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

    Jiangnan Luo, Chun-Yuan Ting ... Chi-Hon Lee
    Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
    1. Cell Biology
    2. Neuroscience

    Dendritic mitochondria reach stable positions during circuit development

    Michelle C Faits, Chunmeng Zhang ... Daniel Kerschensteiner
    Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.
    1. Neuroscience

    Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors

    Anastasiya Zaytseva, Evelina Bouckova ... Seonil Kim
    Ketamine induces the expression of Ca2+-permeable AMPA receptors to enhance synaptic glutamatergic and Ca2+ activity in neurons to cause rapid antidepressant effects.
    1. Cell Biology
    2. Neuroscience

    Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones

    Nickolai V Vysokov, John-Paul Silva ... Yuri A Ushkaryov
    Lasso and latrophilin-1 interact across the synapse, while shed Lasso binds latrophilin-1 on distant growth cones and attracts them, providing a universal mechanism for short- and long-range axonal guidance.