Zora Chui-Kuen Chan, Hiu-Lam Rachel Kwan ... Chi Wai Lee
Postsynaptic MT1-MMP serves as a molecular switch to synaptogenesis by clearing the surrounding ECM environment that allows effective deposition of nerve-derived synaptogenic factors to induce postsynaptic differentiation at developing NMJs.
Jessica Douthit, Ariel Hairston ... Jessica E Treisman
R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.
Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.
Semaphorin7A sculpts the collective arbor architecture of the lateral line nerve and facilitates neural contacts with the hair cells for synaptogenesis during neuromast development in the zebrafish.
In congenital stationary night blindness type 2, Cav3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Cav1.4 in cone synaptogenesis remains intact.
Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
Anastasiya Zaytseva, Evelina Bouckova ... Seonil Kim
Ketamine induces the expression of Ca2+-permeable AMPA receptors to enhance synaptic glutamatergic and Ca2+ activity in neurons to cause rapid antidepressant effects.
Nickolai V Vysokov, John-Paul Silva ... Yuri A Ushkaryov
Lasso and latrophilin-1 interact across the synapse, while shed Lasso binds latrophilin-1 on distant growth cones and attracts them, providing a universal mechanism for short- and long-range axonal guidance.