155 results found
    1. Neuroscience

    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

    Jason D Vevea et al.
    Synaptotagmin 7 is asymmetrically localized to the axonal plasma membrane through γ-secretase processing to promote vesicle docking during short-term synaptic plasticity in mouse hippocampal neurons.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian et al.
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Neuroscience

    Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

    Filippo Ghezzi et al.
    A combined developmental genetics, electrophysiology, and optical approach identify two distinct and dynamic components of the developing neuronal circuit that relay and interpret thalamic input in primary sensory neocortex.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil et al.
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.
    1. Neuroscience

    A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

    Ana C Sias et al.
    The bidirectional orbitofrontal cortex-basolateral amygdala circuit helps us to learn the details of predicted rewarding events and then to use that information to make good reward pursuit decisions.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary et al.
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Neuroscience

    Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

    Briana J Martiszus et al.
    External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.
    1. Neuroscience

    IGF-1 facilitates extinction of conditioned fear

    Laura E Maglio et al.
    Insulin-like growth factor-1 activates the prefrontal cortex and improves the extinction of aversive memories.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar et al.
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.

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